[he's just sort of crouched and squinting in the sun, having given up on shirts himself but not worrying too much about the sun just yet]

We can't just tell PGE2 to take the day off and direct the fever energy elsewhere, or we'll lose activity in the signal transduction pathways that induce vasodilation. That would make the, ah. Heart explode. [rubbing his forehead] We need to reprogram the receptor to turn those "Let's have a fever" signals into something more productive. Since its primary function is a muscle relaxant, we also need a roundabout way to recycle the heat generation.